Pharmacel® 101

Microcrystalline Cellulose (MCC)

Wet Granulation

Pharmacel® 101 Microcrystalline Cellulose (MCC) has been developed specifically as a key component for wet granulation formulations. Using Pharmacel® 101 ensures even distribution of the granulating fluid, and which in turn means uniform granulation and drying processes. Wet granulation with Pharmacel® is a reliable, easily repeatable and robust process, and tablets made using Pharmacel® 101 show excellent properties.

It is possible to unlock production synergies by using wet granulated formulations containing Pharmacel® or Pharmatose® in combination with a superdisintegrant, such as Primojel®. This approach optimises the formulation to give strong tablets with excellent drug dissolution profiles.

Dry Granulation

Pharmacel® Microcrystalline Cellulose (MCC) is also an ideal excipient for use in dry granulated formulations. Ribbons do not stick to the rollers during roller compaction and dry granulation can be used in formulations with a high drug dosage. For dry granulation, as well, Pharmacel® opens up vital production synergies. Used with a brittle excipient, such as SuperTab®21AN anhydrous lactose, the result is an ideal combination of high tablet strength and insensitivity to recompaction, leading to outstandingly robust dry granulation formulations.

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Product application specialist

Sunil Kumar Nataraj
Product Application Specialist

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