Wet granulation of powders is primarily carried out to improve the flow and compactability of a tablet compression mix, and it is probably the most common means of tablet production. The reason for its popularity is that just about any drug of any dose can be processed successfully by wet granulation. The major process steps are dry powder blending, wet granulation with water or a binder solution, drying and granule sizing, addition of extragranular components, lubrication and compaction. Typical wet granulation excipients include a diluent, a binder a disintegrant and a lubricant, and optionally other excipients such as stabilising agents and pigments.
Wet granulation may also be applied to formulations for capsule filling, especially if there is a need to improve the flow to increase the density of the formulation.
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