Dry Granulation is an old technique that is again increasing in popularity. It is used to increase the size of powders to improve flow for tableting and encapsulation, and also to increase the density of formulations for capsule filling if required. It involves the steps of dry powder blending, initial compaction (slugging or roller compaction), milling, addition of extragranular excipients and lubrication before compaction or capsule filling. For tableting it is important to understand the behaviour of the formulation on multiple compaction cycles, because loss of tabletability is a commonly seen phenomenon.
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