Direct Compression is by far the easiest means of processing tablets, because it only involves the main steps of powder blending, lubrication and compaction. Because there is no granulation step to improve flow and compaction it is usually necessary to use excipients specifically designed for direct compression, and engineered to provide the necessary flow and compaction properties. Such materials are sometimes known as “filler-binders”. Despite the availability of these materials, the utility of direct compression may be limited by the dose of drug to be tableted. Other direct compression excipients, such as superdisintegrants are generally the same as those used for wet or dry granulation.
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