What is the difference between Primojel® and Primellose®?
are chemically modified natural polymers of glucose. Primojel® is based on starch and Primellose®
is based on cellulose. The two modifications are introduction of carboxymethyl groups (to promote water ingress) and cross-linking of the polymer chains (to prevent dissolution and development of viscosity).
Does wet granulation affect the efficiency of Primojel® and Primellose®?
No. In fact we recommend that the disintegrants are included, at least in part, during granulation. Tablets containing high levels of insoluble material can suffer from slow disintegration and slow dissolution if all the disintegrant is added in the extragranular phase.
What is the mechanism of Primojel®’s super-disintegrant action?
work by taking up water and swelling. The combination of these two mechanisms is responsible for the superdisintegrant action.
How are Primojel® and Primellose® packed?
Both products are packed in HDPE plastic drums. Size of Primojel®
: 50kg, Size of Primellose®
Where are Primojel® and Primellose® produced? Who does release the product?
are produced in our own production facilities in Foxhol, The Netherlands. After quality inspection, the product is released for shipment to the customer by DFE QA.
What is the shelf-life of Primojel® and Primellose®?
have a shelf-life of 5 years.
Which disintegrants should I use with different filler/binders?
With the SuperTab®
SD, GR and Lactopress Spray Dried and Granulated range of filler binders we recommend either Primojel®
at a starting level of 2% to 4% by weight of the formulation.
With SuperTab® AN and Lactopress® Anhydrous, Primellose® is preferred. For other commonly used filler-binders either Primellose® or Primojel® may be used, and levels of 2 – 4% by weight are usual. Primellose® is preferred when the formulation contains high levels of calcium phosphate.
How should Primojel® and Primellose® be added to a formulation?
It is advised to pass the disintegrants through a sieve before adding. In direct compression simply blend the Primojel®
into the compression mix at a point before lubrication.
In wet granulation we recommend that at least 50% of the Primojel® or Primellose® are added during the granulation stage (intra-granular). The remainder can be added after the drying step and before lubrication.